Predominance of Rotavirus P[4]G2 in a Vaccinated Population, Brazil
نویسندگان
چکیده
We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2. Prospective surveillance is urgently needed.
منابع مشابه
Rotavirus P[4]G2 in a Vaccinated Population, Brazil
To the Editor: Gurgel et al. described the predominance of P[4]G2 rotaviruses in a vaccinated population in Aracaju, northeastern Brazil (1). However, several limitations need to be addressed to avoid misinterpretation of data that could lead to loss of confi dence in the vaccine in Brazil and other countries. Brazil was one of the fi rst countries in Latin America to introduce a live, oral, at...
متن کاملAcute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil.
Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix®) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 20...
متن کاملPredominance of rotavirus genotype G9 during the 1999, 2000, and 2002 seasons among hospitalized children in the city of Salvador, Bahia, Brazil: implications for future vaccine strategies.
Two hundred eight of 648 (32%) diarrheal stool samples collected from hospitalized children under 5 years of age during a 3-year period (1999, 2000, and 2002) in the city of Salvador, in the state of Bahia, Brazil, were rotavirus positive. One hundred sixty-four of 208 (78.8%) rotavirus-positive samples had genotype G9 specificity, predominantly in association with P[8]. Other specificities det...
متن کاملMolecular characterization of group A rotavirus before and after the introduction of vaccines in Brazil.
INTRODUCTION In this study, the molecular characteristics of group A rotavirus (RVA) were compared in samples obtained before and after RVA vaccine-introduction in Brazil. METHODS Eighty samples were screened for the presence of RVA. Positive samples were molecularly analyzed. RESULTS RVA positivity was 16.9%, with a predominance of G2P[4]. Periods: pre-vaccination: predominance of IId (G1)...
متن کاملDetection and characterization of rotavirus G and P types from children participating in a rotavirus vaccine trial in Belém, Brazil.
This study sought the characterization of rotaviruses in a trial with a tetravalent rhesus-human rotavirus vaccine in Belém, Brazil in children who received three doses of vaccine or placebo in the 1st, 3rd and 5th months of life. Rotavirus electropherotypes, subgroups, G serotypes, G, [P] and [P], G genotypes were determined in 93.3%, 95.9%, 93.3%, 73.3%, 95.5% and 92.2% of isolates, respectiv...
متن کامل